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Clinical Question:
Does metabolic syndrome coexist in pre-diabetic patients?
Bottom Line:
Pre-diabetes and the metabolic syndrome frequently coexist in relatively
lean Japanese. This association seems to link with abdominal adiposity and
insulin resistance.
Reference:
New "Pre-diabetes" Category and the Metabolic Syndrome in Japanese.Kanauchi
M, Kawano T, Kanauchi K, Saito Y. Horm Metab Res. 2005 Oct;37(10):622-6.
Synopsis:
Recently, impaired fasting glucose (IFG) was redefined as fasting plasma
glucose of 100 - 125 mg/dl, and individuals with IFG and/or impaired glucose
tolerance (IGT) were referred to as having "pre-diabetes". However, there is
a lack of data using the new definition of IFG and "pre-diabetes". To
examine associations of the metabolic syndrome components with the new
"pre-diabetes" category in relatively lean Japanese. Six hundred and
sixty-one Japanese study participants underwent a 75 g oral glucose
tolerance test. They were classified into three groups-normal (n = 225),
pre-diabetes (n = 308), and diabetes (n = 128). The metabolic syndrome was
defined according to the National Cholesterol Education Program Adult
Treatment Panel III, as modified for waist circumference criteria by the
Regional Office for the Western Pacific Region of WHO. Prevalence of the
metabolic syndrome in each group was 10.7 %, 27.9 %, and 53.9 %,
respectively. Of the metabolic syndrome components, the OR for prevalent
pre-diabetes was 2.00 (95 % CI, 1.73 - 2.31, p < 0.001) for fasting glucose,
1.93 (95 % CI, 1.54 - 2.42, p < 0.001) for waist circumference, and 1.36 (95
% CI, 1.10 - 1.68, p = 0.005) for triglycerides. Similar associations were
found in prevalent diabetes. Insulin resistance assessed using Stumvoll's
index was significantly associated with both pre-diabetes and diabetes. |