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Online Clinical Calculator |
Favourable long term prognosis in
stable angina pectoris
|
An extended follow up of the angina prognosis study in Stockholm (APSIS)
OBJECTIVE:
To evaluate the long term prognosis of patients with stable angina pectoris.
DESIGN: Registry based follow up (median 9.1 years) of patients
participating in the APSIS (angina prognosis study in Stockholm), which was
a double blind, single centre trial of antianginal drug treatment.
PATIENTS:
809 patients (31% women) with stable angina pectoris < 70 (mean (SD) 59 (7)
years at inclusion) and an age and sex matched reference population from the
same catchment area.
INTERVENTIONS:
Double blind treatment with metoprolol or verapamil during 3.4 years
(median), followed by referral for usual care with open treatment.
MAIN OUTCOME MEASURES: Cardiovascular (CV) death and non-fatal myocardial
infarction (MI) in the APSIS cohort and total mortality in comparison with
reference subjects.
RESULTS:
123 patients died (41 MI, 36 other CV causes) and 72 had non-fatal MI.
Mortality (19% v 6%, p < 0.001) and fatal MI (6.6% v 1.6%, p < 0.001) were
increased among male compared with female patients. Diabetes, previous MI,
hypertension, and male sex independently predicted CV mortality (p < 0.001).
Diabetes greatly increased the risk in a small subgroup of female patients.
Male patients had higher mortality than men in the reference population
during the first three years (cumulative absolute difference 3.8%) but
apparently not thereafter. Female patients had similar mortality to women in
the reference population throughout the 9.1 years of observation.
CONCLUSIONS:
Female patients with stable angina had
similar mortality to matched female reference subjects but male patients had
an increased risk. Diabetes, previous MI, hypertension, and male sex were
strong risk factors for CV death or MI.
Reference:
Heart. 2006 Feb;92(2):177-82. Epub 2005 Jun 10 |
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