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Clinical Question:
Aside from a marker for CAD. Is Erectile Dysfunction interdependence to the
occurrence of major coronary events ?
Bottom Line:
Patients with ED have higher estimated probability of presenting segmental
myocardial perfusion and functional contraction impairment and, therefore,
CAD, independent of the aging factor. The authors conclude that ED may be
considered not only a marker for CAD but also a condition related to the
occurrence of major coronary events such as MI and PCTA.
Reference:
Erectile dysfunction: a marker for myocardial perfusion impairment? Ortiz J,
Ortiz ST, Monaco CG, Yamashita CH, Moreira MC, Monaco CA. Arq Bras Cardiol.
2005 Oct;85(4):241-6. Epub 2005 Nov 7.
Study Design:
Prospective study
Synopsis:
To study the correlation between erectile dysfunction (ED) and myocardial
perfusion impairment in men with suspected or diagnosed coronary artery
disease (CAD). In this prospective study a self-administered IIEF-5
questionnaire was answered by 287 patients that underwent myocardial
perfusion imaging under both resting and stress condition with
technetium-99m sestamibi, through gated SPECT nuclear scintigraphy
technique, before and after physical or pharmacological stress. Some degree
of erectile dysfunction (group ED+) was found in 137 (47.8%) patients and in
these, age was significantly higher (60.60+/-9.84 vs 50.67+/-9.94 -
p<0.001)) than in those without erectile dysfunction (group ED-). In the ED+
group, it was observed a higher prevalence of hypertension, diabetes,
myocardial infarction (MI) and percutaneous coronary angioplasty (PCTA).
Regardless of the age factor, ED+ patients also presented higher occurrence
of myocardial perfusion impairment (necrosis and/or ischemia) and left
ventricular systolic wall motion and thickening abnormalities
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